Assay ID | Title | Year | Journal | Article |
AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1375054 | Antiproliferative activity against human A818-6 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375046 | Ratio of IC50 for full-length rat GST-tagged CK1delta to IC50 for rat recombinant CK1delta kinase domain | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375052 | Inhibition of recombinant human ZAP70 at 5 nM to 10 uM using poly (L-glutamic acid-L-tyrosine) as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375050 | Inhibition of recombinant human full length GST/His-tagged ZAP70 expressed in Sf9 cells assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375069 | Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling at 5 uM after 22 hrs by Super-top flash reporter gene assay relative to control | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375040 | Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525426 | Inhibition of Wnt3A lipidation in mouse L cell expressing Wnt3a and overexpressing porcn at 2 uM by detergent solubility fractionation assay | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525433 | Inhibition of HHAT mediated Wnt pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525439 | Inhibition of Wnt3A activity in mouse L cell expressing Wnt3A and STF and overexpressing porcn assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375043 | Inhibition of human recombinant CK1epsilon using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375057 | Antiproliferative activity against human Panc89 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375051 | Inhibition of recombinant human N-terminal FLAG/C-terminal HIS8-tagged TLK2 assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375060 | Antiproliferative activity against human SW620 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525430 | Inhibition of MBOAT2 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525445 | Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as decrease in phosphorylated Lrp6 level at 5 uM after 24 hrs by Western blot analysis | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375059 | Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375039 | Inhibition of human CK1epsilon assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375049 | Inhibition of human recombinant CK1delta assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525422 | Inhibition of porcn-mediated Shh palmitoylation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375037 | Inhibition of full-length rat GST-tagged CK1delta assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375055 | Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525428 | Inhibition of lipidation of Wnt3A expressed in mouse L cell at 2 uM by detergent solubility fractionation assay | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375072 | Inhibition of Wnt/beta-catenin signaling in HEK293T cells after 22 hrs in presence of Wnt3A-conditioned medium by Super-top flash reporter gene assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525432 | Inhibition of GOAT mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525429 | Inhibition of MBOAT5 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375042 | Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525425 | Inhibition of Wnt3A palmitoylation in mouse L cell expressing Wnt3a and overexpressing porcn by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525438 | Inhibition of Wnt3A activity in mouse L cell expressing Wnt3A and STF and overexpressing Evi assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375061 | Antiproliferative activity against human Capan1 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375056 | Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525434 | Inhibition of ACAT mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525424 | Inhibition of porcn-mediated Wnt5A palmitoylation in mouse L cell expressing Wnt5A and STF by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2 uM by autoradiography method | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375044 | Selectivity ratio of IC50 for human CK1epsilon to IC50 for full-length rat GST-tagged CK1delta | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375068 | Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs by Super-top flash reporter gene assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375062 | Inhibition of CK1delta in human PANC1 cells assessed as residual activity at 2.33 uM using GST-tagged p53 (1 to 64 residues) as substrate after 48 hrs in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525431 | Inhibition of MBOAT1 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525427 | Inhibition of palmitoylation of Wnt3A expressed in mouse L cell by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525443 | Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as inhibition of beta-casein accumulation at 5 uM after 24 hrs by Western blot analysis | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID728601 | Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay | 2013 | Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6
| The development of highly potent inhibitors for porcupine. |
AID1375045 | Selectivity ratio of IC50 for human CK1epsilon to IC50 for rat recombinant CK1delta kinase domain | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375074 | Upregulation of renilla luciferase expression in HEK293T cells up to 5 uM after 22 hrs in presence of Wnt3A-conditioned medium by luminescence assay relative to control | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525437 | Inhibition of Wnt3A secretion in mouse L cell expressing Wnt3a overexpressing porcn assessed as decreased Gaussia luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525418 | Effect on porcn Endoplasmic reticulum localization in mouse L cell expressing Wnt and STF | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375053 | Inhibition of recombinant human TLK2 at 5 nM to 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525423 | Inhibition of Notch pathway in HEK293 cells at 2.5 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375038 | Inhibition of rat recombinant CK1delta kinase domain assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525436 | Inhibition of Wnt3A secretion in mouse L cell expressing Wnt3a overexpressing Evi assessed as decreased Gaussia luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525435 | Inhibition of pBSK mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375058 | Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1375073 | Upregulation of renilla luciferase expression in HEK293T cells transfected with Wnt3A-expressing vector up to 5 uM after 22 hrs by luminescence assay relative to control | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525450 | Inhibition of caudal fin regeneration after mechanical resection in zebrafish at 10 uM after 7 days | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525419 | Displacement of IWP-PB from porcn in HEK293 lysate by Western blot analysis | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375041 | Inhibition of full-length rat GST-tagged CK1delta using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID525417 | Increase in porcn levels in mouse L cell expressing Wnt and STF | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID525444 | Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as decrease in phosphorylated Dvl2 level at 5 uM after 24 hrs by Western blot analysis | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. |
AID1375048 | Competitive inhibition of full-length rat GST-tagged CK1delta at IC50 using alpha-casein as substrate after 30 mins in presence of 10 to 500 uM ATP and [gamma-32P]-ATP by Cherenkov counting method | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |