N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide profile

ID Source	ID
PubMed CID	2155128
CHEMBL ID	1257064
CHEBI ID	125649
SCHEMBL ID	12571758

Synonym
EU-0088954
n-(6-methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide
CHEBI:125649
cid 2155128
n-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
AB00668695-01
CHEMBL1257064 ,
nsc753606
nsc-753606
bdbm50428028
FT-0670578
n-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
F0579-0037 ,
686770-61-6
iwp-2 ,
n-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
NCGC00347948-01
S7085
BRD-K82924899-001-01-9
CCG-208106
HY-13912
CS-1578
c22h18n4o2s3
SCHEMBL12571758
iwp 2
wnt inhibitor iwp-2
HB0344
n-(6-methyl-2-benzothiazolyl)-2-[(3 ,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
AC-32858
AKOS024457669
Q27216260
n-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
n-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]
iwp2
DTXSID50366724
iwp-2, >=98% (hplc)
HMS3652J22
NCGC00347948-11
SW066807-3
n -(6-methyl-2-benzothiazolyl)-2-[(3a?4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimaidin-2-yl)thio]-acetamide
EX-A2264
BCP09534
A12707
SB19436
mfcd04457599
n -(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimidin-2-yl)thio]-acetamide
AS-55819
inhibitor of wnt production-2
HY-13912G
CS-0626098
iwp-2 (gmp)
Z2235802202

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Class	Description
organonitrogen heterocyclic compound	Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
organic heterobicyclic compound
organosulfur heterocyclic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Regulation of Wnt / B-catenin signaling by small molecule compounds	0	10

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	26.8370	0.0123	7.9835	43.2770	AID1645841
EWS/FLI fusion protein	Homo sapiens (human)	Potency	18.2095	0.0013	10.1577	42.8575	AID1259252; AID1259253; AID1259255; AID1259256
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Casein kinase I isoform epsilon	Homo sapiens (human)	IC50 (µMol)	4.0300	0.0040	1.1150	9.5000	AID1375043
Casein kinase I isoform delta	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.4300	0.0020	0.2230	0.9300	AID1375040; AID1375041; AID1375042
Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)	IC50 (µMol)	0.1570	0.0001	0.0318	0.1570	AID1375068
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Protein-serine O-palmitoleoyltransferase porcupine	Mus musculus (house mouse)	EC50 (µMol)	0.0300	0.0300	0.0300	0.0300	AID728601
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
DNA repair	Casein kinase I isoform epsilon	Homo sapiens (human)
protein phosphorylation	Casein kinase I isoform epsilon	Homo sapiens (human)
protein localization	Casein kinase I isoform epsilon	Homo sapiens (human)
negative regulation of Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
negative regulation of protein binding	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Casein kinase I isoform epsilon	Homo sapiens (human)
regulation of protein localization	Casein kinase I isoform epsilon	Homo sapiens (human)
circadian regulation of gene expression	Casein kinase I isoform epsilon	Homo sapiens (human)
regulation of circadian rhythm	Casein kinase I isoform epsilon	Homo sapiens (human)
circadian behavior	Casein kinase I isoform epsilon	Homo sapiens (human)
canonical Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of amyloid-beta formation	Casein kinase I isoform epsilon	Homo sapiens (human)
cellular response to nerve growth factor stimulus	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of non-canonical Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform epsilon	Homo sapiens (human)
endocytosis	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
signal transduction	Casein kinase I isoform epsilon	Homo sapiens (human)
protein lipidation	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
glycoprotein metabolic process	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
Wnt signaling pathway	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
protein palmitoleylation	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levels	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
lipid modification	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
protein palmitoylation	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
Wnt protein secretion	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA binding	Casein kinase I isoform epsilon	Homo sapiens (human)
protein kinase activity	Casein kinase I isoform epsilon	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform epsilon	Homo sapiens (human)
protein binding	Casein kinase I isoform epsilon	Homo sapiens (human)
ATP binding	Casein kinase I isoform epsilon	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform epsilon	Homo sapiens (human)
palmitoleoyltransferase activity	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
Wnt-protein binding	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
O-acyltransferase activity	Protein-serine O-palmitoleoyltransferase porcupine	Mus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Casein kinase I isoform epsilon	Homo sapiens (human)
nucleoplasm	Casein kinase I isoform epsilon	Homo sapiens (human)
cytoplasm	Casein kinase I isoform epsilon	Homo sapiens (human)
cytosol	Casein kinase I isoform epsilon	Homo sapiens (human)
growth cone	Casein kinase I isoform epsilon	Homo sapiens (human)
neuronal cell body	Casein kinase I isoform epsilon	Homo sapiens (human)
ribonucleoprotein complex	Casein kinase I isoform epsilon	Homo sapiens (human)
cytoplasm	Casein kinase I isoform epsilon	Homo sapiens (human)
nucleus	Casein kinase I isoform epsilon	Homo sapiens (human)
endoplasmic reticulum	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
endoplasmic reticulum membrane	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
glutamatergic synapse	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
AMPA glutamate receptor complex	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
membrane	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
endoplasmic reticulum	Protein-serine O-palmitoleoyltransferase porcupine	Homo sapiens (human)
endoplasmic reticulum membrane	Protein-serine O-palmitoleoyltransferase porcupine	Mus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (110)

Assay ID	Title	Year	Journal	Article
AID1347411	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347090	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347097	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347115	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347105	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347119	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347113	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347109	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347122	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347112	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347114	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347110	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells)	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347116	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347124	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347129	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347125	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1347100	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347127	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347123	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347126	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347099	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347118	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347128	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347117	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347121	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347111	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1375054	Antiproliferative activity against human A818-6 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375046	Ratio of IC50 for full-length rat GST-tagged CK1delta to IC50 for rat recombinant CK1delta kinase domain	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375052	Inhibition of recombinant human ZAP70 at 5 nM to 10 uM using poly (L-glutamic acid-L-tyrosine) as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375050	Inhibition of recombinant human full length GST/His-tagged ZAP70 expressed in Sf9 cells assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375069	Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling at 5 uM after 22 hrs by Super-top flash reporter gene assay relative to control	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375040	Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525426	Inhibition of Wnt3A lipidation in mouse L cell expressing Wnt3a and overexpressing porcn at 2 uM by detergent solubility fractionation assay	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525433	Inhibition of HHAT mediated Wnt pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525439	Inhibition of Wnt3A activity in mouse L cell expressing Wnt3A and STF and overexpressing porcn assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375043	Inhibition of human recombinant CK1epsilon using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375057	Antiproliferative activity against human Panc89 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375051	Inhibition of recombinant human N-terminal FLAG/C-terminal HIS8-tagged TLK2 assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375060	Antiproliferative activity against human SW620 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525430	Inhibition of MBOAT2 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525445	Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as decrease in phosphorylated Lrp6 level at 5 uM after 24 hrs by Western blot analysis	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375059	Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375039	Inhibition of human CK1epsilon assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375049	Inhibition of human recombinant CK1delta assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525422	Inhibition of porcn-mediated Shh palmitoylation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375037	Inhibition of full-length rat GST-tagged CK1delta assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375055	Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525428	Inhibition of lipidation of Wnt3A expressed in mouse L cell at 2 uM by detergent solubility fractionation assay	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375072	Inhibition of Wnt/beta-catenin signaling in HEK293T cells after 22 hrs in presence of Wnt3A-conditioned medium by Super-top flash reporter gene assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525432	Inhibition of GOAT mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525429	Inhibition of MBOAT5 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375042	Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525425	Inhibition of Wnt3A palmitoylation in mouse L cell expressing Wnt3a and overexpressing porcn by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525438	Inhibition of Wnt3A activity in mouse L cell expressing Wnt3A and STF and overexpressing Evi assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375061	Antiproliferative activity against human Capan1 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375056	Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525434	Inhibition of ACAT mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525424	Inhibition of porcn-mediated Wnt5A palmitoylation in mouse L cell expressing Wnt5A and STF by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2 uM by autoradiography method	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375044	Selectivity ratio of IC50 for human CK1epsilon to IC50 for full-length rat GST-tagged CK1delta	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375068	Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs by Super-top flash reporter gene assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375062	Inhibition of CK1delta in human PANC1 cells assessed as residual activity at 2.33 uM using GST-tagged p53 (1 to 64 residues) as substrate after 48 hrs in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525431	Inhibition of MBOAT1 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525427	Inhibition of palmitoylation of Wnt3A expressed in mouse L cell by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525443	Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as inhibition of beta-casein accumulation at 5 uM after 24 hrs by Western blot analysis	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID728601	Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay	2013	Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6	The development of highly potent inhibitors for porcupine.
AID1375045	Selectivity ratio of IC50 for human CK1epsilon to IC50 for rat recombinant CK1delta kinase domain	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375074	Upregulation of renilla luciferase expression in HEK293T cells up to 5 uM after 22 hrs in presence of Wnt3A-conditioned medium by luminescence assay relative to control	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525437	Inhibition of Wnt3A secretion in mouse L cell expressing Wnt3a overexpressing porcn assessed as decreased Gaussia luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525418	Effect on porcn Endoplasmic reticulum localization in mouse L cell expressing Wnt and STF	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375053	Inhibition of recombinant human TLK2 at 5 nM to 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525423	Inhibition of Notch pathway in HEK293 cells at 2.5 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375038	Inhibition of rat recombinant CK1delta kinase domain assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525436	Inhibition of Wnt3A secretion in mouse L cell expressing Wnt3a overexpressing Evi assessed as decreased Gaussia luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525435	Inhibition of pBSK mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375058	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375073	Upregulation of renilla luciferase expression in HEK293T cells transfected with Wnt3A-expressing vector up to 5 uM after 22 hrs by luminescence assay relative to control	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525450	Inhibition of caudal fin regeneration after mechanical resection in zebrafish at 10 uM after 7 days	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525419	Displacement of IWP-PB from porcn in HEK293 lysate by Western blot analysis	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375041	Inhibition of full-length rat GST-tagged CK1delta using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525417	Increase in porcn levels in mouse L cell expressing Wnt and STF	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525444	Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as decrease in phosphorylated Dvl2 level at 5 uM after 24 hrs by Western blot analysis	2009	Nature chemical biology, Feb, Volume: 5, Issue:2	Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375048	Competitive inhibition of full-length rat GST-tagged CK1delta at IC50 using alpha-casein as substrate after 30 mins in presence of 10 to 500 uM ATP and [gamma-32P]-ATP by Cherenkov counting method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (7.69)	29.6817
2010's	5 (38.46)	24.3611
2020's	7 (53.85)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
iwr-1 exo IWR-1-exo : A dicarboximide having an exo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. It is a weak axin stabilizer, an analogue of IWR-1-endo.	2.05	1	bridged compound; dicarboximide	axin stabilizer
ic 261 IC 261: a caseine kinase-1 inhibitor; structure in first source	2.17	1
4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine PF-670462 free base : A member of the class of imidazoles that is 1H-imidazole which is substituted at positions 1, 4, and 5 by cyclohexyl, p-fluorophenyl, and 2-aminopyrimidin-4-yl groups, respectively. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).	2.17	1	aminopyrimidine; imidazoles; monofluorobenzenes	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
iwr-1 endo IWR-1-endo : A dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group.	2.05	1	benzamides; bridged compound; dicarboximide; quinolines	axin stabilizer; Wnt signalling inhibitor
wnt-c59 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide: a PORCN acyltransferase inhibitor; structure in first source	2.17	1
sr-3029 SR-3029: highly selective casein kinase 1delta/1epsilon inhibitor with potent antiproliferative properties; structure in first source	2.17	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.05	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.05	1
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Cross-References

Synonyms (52)

Research Excerpts

Bioavailability

Drug Classes (3)

Pathways (1)

Protein Targets (6)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (26)

Molecular Functions (9)

Ceullar Components (12)

Bioassays (110)

Research

Studies (13)

Market Indicators

Research Demand Index: 12.99

Study Types

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Cross-References

Synonyms (52)

Research Excerpts

Bioavailability

Drug Classes (3)

Pathways (1)

Protein Targets (6)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (26)

Molecular Functions (9)

Ceullar Components (12)

Bioassays (110)

Research

Studies (13)

Market Indicators

Research Demand Index: 12.99

Study Types

Related Drugs (6)

Related Conditions (7)