Page last updated: 2024-12-09

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID2155128
CHEMBL ID1257064
CHEBI ID125649
SCHEMBL ID12571758

Synonyms (52)

Synonym
EU-0088954
n-(6-methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide
CHEBI:125649
cid 2155128
n-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
AB00668695-01
CHEMBL1257064 ,
nsc753606
nsc-753606
bdbm50428028
FT-0670578
n-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
F0579-0037 ,
686770-61-6
iwp-2 ,
n-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
NCGC00347948-01
S7085
BRD-K82924899-001-01-9
CCG-208106
HY-13912
CS-1578
c22h18n4o2s3
SCHEMBL12571758
iwp 2
wnt inhibitor iwp-2
HB0344
n-(6-methyl-2-benzothiazolyl)-2-[(3 ,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
AC-32858
AKOS024457669
Q27216260
n-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
n-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]
iwp2
DTXSID50366724
iwp-2, >=98% (hplc)
HMS3652J22
NCGC00347948-11
SW066807-3
n -(6-methyl-2-benzothiazolyl)-2-[(3a?4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimaidin-2-yl)thio]-acetamide
EX-A2264
BCP09534
A12707
SB19436
mfcd04457599
n -(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimidin-2-yl)thio]-acetamide
AS-55819
inhibitor of wnt production-2
HY-13912G
CS-0626098
iwp-2 (gmp)
Z2235802202

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
organonitrogen heterocyclic compoundAny organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
organic heterobicyclic compound
organosulfur heterocyclic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Regulation of Wnt / B-catenin signaling by small molecule compounds010

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency26.83700.01237.983543.2770AID1645841
EWS/FLI fusion proteinHomo sapiens (human)Potency18.20950.001310.157742.8575AID1259252; AID1259253; AID1259255; AID1259256
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Casein kinase I isoform epsilonHomo sapiens (human)IC50 (µMol)4.03000.00401.11509.5000AID1375043
Casein kinase I isoform deltaRattus norvegicus (Norway rat)IC50 (µMol)0.43000.00200.22300.9300AID1375040; AID1375041; AID1375042
Protein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)IC50 (µMol)0.15700.00010.03180.1570AID1375068
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Protein-serine O-palmitoleoyltransferase porcupineMus musculus (house mouse)EC50 (µMol)0.03000.03000.03000.0300AID728601
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (26)

Processvia Protein(s)Taxonomy
DNA repairCasein kinase I isoform epsilonHomo sapiens (human)
protein phosphorylationCasein kinase I isoform epsilonHomo sapiens (human)
protein localizationCasein kinase I isoform epsilonHomo sapiens (human)
negative regulation of Wnt signaling pathwayCasein kinase I isoform epsilonHomo sapiens (human)
negative regulation of protein bindingCasein kinase I isoform epsilonHomo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic processCasein kinase I isoform epsilonHomo sapiens (human)
regulation of protein localizationCasein kinase I isoform epsilonHomo sapiens (human)
circadian regulation of gene expressionCasein kinase I isoform epsilonHomo sapiens (human)
regulation of circadian rhythmCasein kinase I isoform epsilonHomo sapiens (human)
circadian behaviorCasein kinase I isoform epsilonHomo sapiens (human)
canonical Wnt signaling pathwayCasein kinase I isoform epsilonHomo sapiens (human)
positive regulation of amyloid-beta formationCasein kinase I isoform epsilonHomo sapiens (human)
cellular response to nerve growth factor stimulusCasein kinase I isoform epsilonHomo sapiens (human)
positive regulation of non-canonical Wnt signaling pathwayCasein kinase I isoform epsilonHomo sapiens (human)
peptidyl-serine phosphorylationCasein kinase I isoform epsilonHomo sapiens (human)
endocytosisCasein kinase I isoform epsilonHomo sapiens (human)
positive regulation of canonical Wnt signaling pathwayCasein kinase I isoform epsilonHomo sapiens (human)
signal transductionCasein kinase I isoform epsilonHomo sapiens (human)
protein lipidationProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
glycoprotein metabolic processProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
Wnt signaling pathwayProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
protein palmitoleylationProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levelsProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
lipid modificationProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
protein palmitoylationProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
Wnt protein secretionProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
RNA bindingCasein kinase I isoform epsilonHomo sapiens (human)
protein kinase activityCasein kinase I isoform epsilonHomo sapiens (human)
protein serine/threonine kinase activityCasein kinase I isoform epsilonHomo sapiens (human)
protein bindingCasein kinase I isoform epsilonHomo sapiens (human)
ATP bindingCasein kinase I isoform epsilonHomo sapiens (human)
protein serine kinase activityCasein kinase I isoform epsilonHomo sapiens (human)
palmitoleoyltransferase activityProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
Wnt-protein bindingProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
O-acyltransferase activityProtein-serine O-palmitoleoyltransferase porcupineMus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
nucleusCasein kinase I isoform epsilonHomo sapiens (human)
nucleoplasmCasein kinase I isoform epsilonHomo sapiens (human)
cytoplasmCasein kinase I isoform epsilonHomo sapiens (human)
cytosolCasein kinase I isoform epsilonHomo sapiens (human)
growth coneCasein kinase I isoform epsilonHomo sapiens (human)
neuronal cell bodyCasein kinase I isoform epsilonHomo sapiens (human)
ribonucleoprotein complexCasein kinase I isoform epsilonHomo sapiens (human)
cytoplasmCasein kinase I isoform epsilonHomo sapiens (human)
nucleusCasein kinase I isoform epsilonHomo sapiens (human)
endoplasmic reticulumProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
endoplasmic reticulum membraneProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
glutamatergic synapseProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
AMPA glutamate receptor complexProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
membraneProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
endoplasmic reticulumProtein-serine O-palmitoleoyltransferase porcupineHomo sapiens (human)
endoplasmic reticulum membraneProtein-serine O-palmitoleoyltransferase porcupineMus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (110)

Assay IDTitleYearJournalArticle
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347115qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347119qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347113qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347109qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347122qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347112qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347114qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347110qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells)2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347116qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347124qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347129qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347125qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347127qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347123qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347126qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347118qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347128qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347117qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347121qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347111qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1375054Antiproliferative activity against human A818-6 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375046Ratio of IC50 for full-length rat GST-tagged CK1delta to IC50 for rat recombinant CK1delta kinase domain2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375052Inhibition of recombinant human ZAP70 at 5 nM to 10 uM using poly (L-glutamic acid-L-tyrosine) as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375050Inhibition of recombinant human full length GST/His-tagged ZAP70 expressed in Sf9 cells assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375069Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling at 5 uM after 22 hrs by Super-top flash reporter gene assay relative to control2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375040Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525426Inhibition of Wnt3A lipidation in mouse L cell expressing Wnt3a and overexpressing porcn at 2 uM by detergent solubility fractionation assay2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525433Inhibition of HHAT mediated Wnt pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525439Inhibition of Wnt3A activity in mouse L cell expressing Wnt3A and STF and overexpressing porcn assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375043Inhibition of human recombinant CK1epsilon using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375057Antiproliferative activity against human Panc89 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375051Inhibition of recombinant human N-terminal FLAG/C-terminal HIS8-tagged TLK2 assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375060Antiproliferative activity against human SW620 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525430Inhibition of MBOAT2 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525445Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as decrease in phosphorylated Lrp6 level at 5 uM after 24 hrs by Western blot analysis2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375059Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375039Inhibition of human CK1epsilon assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375049Inhibition of human recombinant CK1delta assessed as residual activity at 1 uM after 60 mins in presence of [gamma-33P]-ATP by scintillation counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525422Inhibition of porcn-mediated Shh palmitoylation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375037Inhibition of full-length rat GST-tagged CK1delta assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375055Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525428Inhibition of lipidation of Wnt3A expressed in mouse L cell at 2 uM by detergent solubility fractionation assay2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375072Inhibition of Wnt/beta-catenin signaling in HEK293T cells after 22 hrs in presence of Wnt3A-conditioned medium by Super-top flash reporter gene assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525432Inhibition of GOAT mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525429Inhibition of MBOAT5 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375042Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525425Inhibition of Wnt3A palmitoylation in mouse L cell expressing Wnt3a and overexpressing porcn by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525438Inhibition of Wnt3A activity in mouse L cell expressing Wnt3A and STF and overexpressing Evi assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375061Antiproliferative activity against human Capan1 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375056Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525434Inhibition of ACAT mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525424Inhibition of porcn-mediated Wnt5A palmitoylation in mouse L cell expressing Wnt5A and STF by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2 uM by autoradiography method2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375044Selectivity ratio of IC50 for human CK1epsilon to IC50 for full-length rat GST-tagged CK1delta2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375068Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs by Super-top flash reporter gene assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375062Inhibition of CK1delta in human PANC1 cells assessed as residual activity at 2.33 uM using GST-tagged p53 (1 to 64 residues) as substrate after 48 hrs in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525431Inhibition of MBOAT1 mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525427Inhibition of palmitoylation of Wnt3A expressed in mouse L cell by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525443Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as inhibition of beta-casein accumulation at 5 uM after 24 hrs by Western blot analysis2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID728601Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay2013Journal of medicinal chemistry, Mar-28, Volume: 56, Issue:6
The development of highly potent inhibitors for porcupine.
AID1375045Selectivity ratio of IC50 for human CK1epsilon to IC50 for rat recombinant CK1delta kinase domain2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375074Upregulation of renilla luciferase expression in HEK293T cells up to 5 uM after 22 hrs in presence of Wnt3A-conditioned medium by luminescence assay relative to control2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525437Inhibition of Wnt3A secretion in mouse L cell expressing Wnt3a overexpressing porcn assessed as decreased Gaussia luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525418Effect on porcn Endoplasmic reticulum localization in mouse L cell expressing Wnt and STF2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375053Inhibition of recombinant human TLK2 at 5 nM to 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525423Inhibition of Notch pathway in HEK293 cells at 2.5 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375038Inhibition of rat recombinant CK1delta kinase domain assessed as residual activity at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525436Inhibition of Wnt3A secretion in mouse L cell expressing Wnt3a overexpressing Evi assessed as decreased Gaussia luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525435Inhibition of pBSK mediated Wnt3a pathway activity in mouse L cell expressing Wnt3a assessed as decreased firefly luciferase reporter expression at 0.25 uM to 1 uM2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375058Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1375073Upregulation of renilla luciferase expression in HEK293T cells transfected with Wnt3A-expressing vector up to 5 uM after 22 hrs by luminescence assay relative to control2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525450Inhibition of caudal fin regeneration after mechanical resection in zebrafish at 10 uM after 7 days2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525419Displacement of IWP-PB from porcn in HEK293 lysate by Western blot analysis2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375041Inhibition of full-length rat GST-tagged CK1delta using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID525417Increase in porcn levels in mouse L cell expressing Wnt and STF2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID525444Inhibition of Wnt3A/beta-casein pathway activity in mouse L cell expressing Wnt3a assessed as decrease in phosphorylated Dvl2 level at 5 uM after 24 hrs by Western blot analysis2009Nature chemical biology, Feb, Volume: 5, Issue:2
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
AID1375048Competitive inhibition of full-length rat GST-tagged CK1delta at IC50 using alpha-casein as substrate after 30 mins in presence of 10 to 500 uM ATP and [gamma-32P]-ATP by Cherenkov counting method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's5 (38.46)24.3611
2020's7 (53.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.99 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]